REXEED SX High Flux DRY Dialyzers

Asahi REXEED SX Polysulfone REXBRANE Dialyzers

REXEED SX - Single Use, High Flux, Dry Dialyzers
Asahi's unique membrane technology results in less stimulation to blood components.

Asahi has achieved a new level of overall performance in dialyzer design by combining the new polysulfone membrane REXBRANE™ with a new jacket design allowing for optimum flow dynamics. Incorporated on the inner surface is Asahi's unique hydrophilic gel layer technology. This minimizes blood membrane interaction and plays a crucial role in anti-coagulation requirements.

• Surface areas from 1.5m2 - 2.5m2	• REXBRANE membrane
• X- jacket design for improved flow dynamics	• ETO free and E-Beam sterilized
• Exceptional toxin removal	• Efficient heparin utilization
• Required priming volume reduced to 500mL	• Inner gel layer reduces platelet activation

Specifications
Performance
SX Comparison
Flow Dynamics
Biocompatibility
Priming Chart
Products

REXEED SX Specifications
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	REXEED-15SX	REXEED-18SX	REXEED-21SX	REXEED-25SX
Inside Diameter of Hollow Fiber (um)	185
Wall Thickness of Hollow Fiber (um)	35
Effective Surface Area (m2)	1.5	1.8	2.1	2.5
Priming Volume (mL)	88	100	119	137
Max. TMP	66kPa (500 mmHg)
Dimensions (mm[L] x mm [DJ])	334(L) x 38(D)	334(L) x 41(D)	334(L) x 43(D)	334(L) x 47(D)
Sterilization	Electron Beam

Fine Tuned Technology

E-Beam Serialization - Electron-beam sterilization, a newly developed technology, is used in REXEED SX dialyzers.

Color-Coded Headers - Red / Blue color coded headers are used for easier distinction when connecting REXEED SX dialyzers to a dialysis machine and blood tubing set.

Required Fluid Volume for Priming Reduced to 500 mL - Since the fluid volume required for priming is less using REXEED SX technology, the valuable time of medical personnel can be saved and the total cost of the dialysis treatment is reduced.

Reduced Size and Weight - The reduced size and weight of the models in the REXEED SX series afford easy handling.

REXEED SX Dialyzer Performance
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Performance (in vitro)
	REXEED-15SX				REXEED-18SX
	Qd=500mL/min			Qd=800 mL/min	Qd=500mL/min			Qd=800 mL/min
Clearance(mL/min)	Qb=200 mL/min	Qb=300 mL/min	Qb=400 mL/min	Qb=400 mL/min	Qb=200 mL/min	Qb=300 mL/min	Qb=400 mL/min	Qb=400 mL/min
Urea	197	275	329	363	198	280	337	370
Creatinine	193	261	303	339	195	268	313	349
Phosphate	188	247	281	314	192	256	293	326
Vitamin B12	152	181	198	219	160	192	211	233
KOA (urea)(mL/min)	1421				1576
KUF(mL/hr/mmHg)	75				82

	REXEED-21SX				REXEED-25SX
	Qd=500mL/min			Qd=800 mL/min	Qd=500mL/min			Qd=800 mL/min
Clearance(mL/min)	Qb=200 mL/min	Qb=300 mL/min	Qb=400 mL/min	Qb=400 mL/min	Qb=200 mL/min	Qb=300 mL/min	Qb=400 mL/min	Qb=400 mL/min
Urea	199	284	347	378	199	287	355	384
Creatinine	197	275	326	361	198	281	335	369
Phosphate	195	266	307	341	197	273	317	352
Vitamin B12	168	206	227	251	174	218	240	266
KOA (urea)(mL/min)	1809				2052
KUF(mL/hr/mmHg)	93				104

KUF: with bovine blood, TP=60+-5 g/L. Hct.=32+-2%, Qb=300 mL/min • Clearance: Qf=0 mL/min • KoA: Qb=400 mL/min, Qd= 800mL/min, Qf=800 mL/min, Qf=0 mL/min

REXEED SX Series Comparison to US Competitors

Urea Clearance Comparison

With regard to small molecule clearance, REXEED SX dialyzers showed the highest level of performance compared to other synthetic membrane dialyzers.
This excellent clearance is attributed to Asahi's superior spinning technology and optimization achieved by the membrane structure and the improved housing design of REXEED SX dialyzers.

Small molecule clearance: all data are as per the manufacturer's specifications for in vitro procedures. Data obtained from product catalog.

REXEED SX Series Dialyzers Urea Comparison

Performance in-vetro REXEED SX Series vs US Competitors - Print (PDF)

	Surface Area (m2)	Priming Volume (m2)	Clearance Qb300, Qd500				Clearance Qb400, Qd500				Clearance Qb400, Qd800				KoA Urea
	Surface Area (m2)	Priming Volume (m2)	Urea	Creatinine	Phosphate	Vit B12	Urea	Creatinine	Phosphate	Vit B12	Urea	Creatinine	Phosphate	Vit B12
REXEED-15SX	1.5	88	275	261	247	181	329	303	281	198	363	339	314	219	1421
Optiflux F160NR	1.5	83	266	238	230	152	308	264	275	157	344	295	296	173	1064
Optiflux F180NR	1.8	99	274	251	238	168	323	286	287	178	358	316	314	203	1239
Polyflux 140H	1.4	94	262	232	220	149	309	266	250	163	-	-	-	-	1040
Polyflux 170H	1.7	115	270	243	232	162	321	281	266	178	-	-	-	-	1190
Xenium 150	1.5	91	269	251	233	174	313	285	262	192	349	324	296	218	1123

	Surface Area (m2)	Priming Volume (m2)	Clearance Qb300, Qd500				Clearance Qb400, Qd500				Clearance Qb400, Qd800				KoA Urea
	Surface Area (m2)	Priming Volume (m2)	Urea	Creatinine	Phosphate	Vit B12	Urea	Creatinine	Phosphate	Vit B12	Urea	Creatinine	Phosphate	Vit B12
REXEED-18SX	1.8	100	280	268	256	192	337	313	293	211	370	349	326	233	1576
Optiflux F180NR	1.8	99	274	251	238	168	323	286	287	178	358	316	314	203	1239
Optiflux F200NR	20	112	277	253	250	173	330	289	290	189	364	325	319	206	1317
Polyflux210H	2.1	125	281	259	249	183	339	303	289	203	-	-	-	-	1500
Xenium 170	1.7	99	274	259	240	185	324	293	269	202	359	330	300	225	1239

	Surface Area (m2)	Priming Volume (m2)	Clearance Qb300, Qd500				Clearance Qb400, Qd500				Clearance Qb400, Qd800				KoA Urea
	Surface Area (m2)	Priming Volume (m2)	Urea	Creatinine	Phosphate	Vit B12	Urea	Creatinine	Phosphate	Vit B12	Urea	Creatinine	Phosphate	Vit B12
REXEED-21SX	2.1	119	284	275	266	206	347	326	307	227	378	361	341	251	1809
Optiflux F200NR	2.0	112	277	253	250	173	330	289	290	189	364	325	319	206	1317
Polyflux210H	2.1	125	281	259	249	183	339	303	289	203	-	-	-	-	1500
Xenium 190	1.9	114	282	269	250	197	336	315	288	218	369	349	320	247	1487
Xenium 210	2.1	126	285	272	253	200	338	316	293	220	371	352	325	249	1614

	Surface Area (m2)	Priming Volume (m2)	Clearance Qb300, Qd500				Clearance Qb400, Qd500				Clearance Qb400, Qd800				KoA Urea
	Surface Area (m2)	Priming Volume (m2)	Urea	Creatinine	Phosphate	Vit B12	Urea	Creatinine	Phosphate	Vit B12	Urea	Creatinine	Phosphate	Vit B12
REXEED-25SX	2.5	137	287	281	273	218	355	335	317	240	384	369	352	266	2052
Optiflux F200NR	2.0	112	277	253	250	173	330	289	290	189	364	325	319	206	1317
Polyflux210H	2.1	125	281	259	249	183	339	303	289	203	-	-	-	-	1500
Xenium 210	2.1	126	285	272	253	200	338	316	293	220	371	352	325	249	1614

Building a Better Dialyzer

Careful design of the fiber shape and fiber bundle, combined with improved geometry of the housing - a short tapered housing and an extended baffle - enable rapid and uniform penetration of dialysate throughout the entire fiber bundle, improving the diffusive clearances of REXEED SX dialyzers.

Straight fibers, a non-tapered housing and a partial baffle in the header can cause dialysate to enter the fiber bundle with asymmetric flow patterns.

Flow Distribution of Dialysate

Dye was injected into the dialysate inlet port, with dialysate flow at 500 mL/min, then fractions were collected at the outlet port and measured for dye concentration by absorbance.

REXEED SX dialyzer shows a homogeneous dialysate distribution figure (left), while the other dialyzer exhibits an uneven distribution of the dialysate flow (right).

A sharp, symmetrical peak indicates rapid and complete penetration of dye into the center of the fiber bundle to give uniform flow distribution, proving the benefits of fiber bundle and housing design optimization.

Superior Biocompatibility - Less Stimulation to Blood Components

On exposure to water, the hydrophilic gel layer formed on the inner surface of the REXEED SX membrane is softer than that formed in the case of other membranes, as shown in the graph below.
This is also one of the major salient features of REXEED SX. A softer inner surface helps to alleviate blood-membrane interaction.

Softness Of The Hydrophilic Layer On The Surface of Internal Membrane

Each membrane was incubated in distilled water for 30 minutes, and then, force-distance curve measurements using Atomic Force Microscopy (AFM) were performed to ensure softness of the inner surface of the membrane.
Each parameter was measured 100 times at different points, and then, the average and standard deviation were calculated.
The major axis of each ellipse shows the standard deviation and the center shows the average value.

The above diagrams are schematic representations of the platelet-membrane interaction. If platelets come in direct contact with the membrane surface, they may be activated, leading to adhesion to the membrane surface. The coagulation system is also highly susceptible to such activation.
The hydrophilic gel layer on the REXEED SX membrane inner surface is designed to suchion the platelets and other blood components from activation caused by blood-membrane interaction.

REXEED SX Priming Chart
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It is important to remember that this diagram is intended to be used as a quick reference guide. Please refer to the IFU enclosed in each carton of dialyzers for more detailed information. It is important to use aseptic technique throughout this procedure.

Priming Procedure

STEP 1:
Position the dialyzer on the machine with the venous header (blue) up.

REXEED SX Priming Procedure Step 2 STEP 2:
Place arterial and venous bloodlines on the machine according to manufacturer's IFU. Close all small clamps.

STEP 3:
Connect 1-liter bag of 0.9% saline to the I.V. administration set.
Note: Saline volume may be determined by unit policy.

STEP 4:
Aseptically attach both arterial and venous bloodlines to appropriate dialyzer connector. (arterial is color-coded red and venous is color-coded blue).

STEP 5:
Open saline clamps and allow patient end of arterial line to fill with saline by gravity. Please note that all drip chambers should be maintained at approximately 3/4 full depending on manufacture's IFU. Close bloodline arterial tubing clamp.

STEP 6:
Open all necessary clamps and start blood pump at slow flow rate (approximately 100mL.min) to prime arterial bloodline, dialyzer and venous bloodline. Be sure to fill drip chambers (if present) to appropriate levels to avoid saline-air mix in bloodline. Ensure that all air is removed from blood pump segment.

STEP 7: Attach dialysate lines to the dialyzer and begin dialysate flow with minimum UF.

STEP 8: Briefly pinch and release either the arterial or venous blood tubing near the dialyzer to assist in purging residual air from the fibers. (this process may be continued throughout the priming process until air fails to accumulate in the header).

STEP 9:
GENTLY tilt and tap the venous dialyzer header to remove accumulated air. (Remember that it is possible to remove air only when the dialyzer is in the venous header up position))

STEP 10:
Continue priming process until 500 mL total saline has passed through the dialyzer and no further air can be removed. Note: Saline volume may be determined by unit policy. If air bubbles remain, continue priming with additional saline until clear. Replace empty saline bag.

Step 11:
This completes priming of the ASAHI dry-packed dialyzer. Treatment may begin, or, if it is normal unit procedure, it is possible to recirculate saline until treatment begins by connecting the patient ends of the arterial and venous bloodlines, opening the saline clamp and resuming blood pump at a slow rate. As treatment begins, dialyzer may be rotated arterial end up.

REXEED SX

REXEED SX - Single Use, High Flux, Dry Dialyzers
Product	Size M²	Priming Volume	Use	Type	Membrane	Sterilization	KOA (Urea)
REXEED 15SX	1.5	88	Single	Dry	Polysolfone	E-Beam	1421
REXEED 18SX	1.8	100	Single	Dry	Polysolfone	E-Beam	1576
REXEED 21SX	2.1	119	Single	Dry	Polysolfone	E-Beam	1809
REXEED 25SX	2.5	137	Single	Dry	Polysolfone	E-Beam	2052