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REXEED S / R Single and Multiple use dialyzers

REXEED S - Single Use, High Flux, Wet, Dialyzers
REXEED R - Multiple Use, High Flux, Wet, Dialyzers

With the REXEED dialyzer, Asahi has achieved a new level of overall performance in dialyzer design by combining the polysulfone membrane REXBRANE with a jacket design that allows for optimum flow dynamics. Incorporated on the inner surface is Asahi's unique hydrophilic gel layer technology.
This minimizes blood membrane interaction and plays a crucial roll in ANTICOAGULATION requiring, LESS HEPARIN!!

REXEED S = Single-Use REXEED R = Multiple Use
• Largest surface area available • Minimal Albumin Loss
• ETO free and Gamma sterilized • X-Jacket design for improved flow dynamics
• High middle molecule removal • Exceptional urea, creatinine & phosphate clearances
• Proprietary fiber inner gel layer minimizes platelet activation
  • Specifications
  • Performance
  • S Comparison
  • R Comparison
  • Balanced Clearances
  • Flow Dynamics
  • Priming Chart
  • Products

REXEED S / R Specifications

  REXEED-15S /R REXEED-18S / R REXEED-21S / R REXEED-25S / R
Inside Diameter of Hollow Fiber (um) 185
Wall Thickness of Hollow Fiber (um) 45
Effective Surface Area (m2) 1.5 1.8 2.1 2.5
Priming Volume (mL) 82 95 112 128
Max. TMP 66kPa (500 mmHg)
Dimensions (mm[L] x mm [DJ]) 334(L) x 41(D) 334(L) x 43(D) 334(L) x 47(D) 334(L) x 50(D)
Sterilization Gamma-Ray

 

REXEED S / R Performance (in vitro)

Performance (in vitro)
  REXEED-15S / R   REXEED-18S / R
Qd=500mL/min Qd=800 mL/min Qd=500mL/min Qd=800 mL/min
Clearance(mL/min) Qb=200 mL/min Qb=300 mL/min Qb=400 mL/min Qb=400 mL/min Qb=200 mL/min Qb=300 mL/min Qb=400 mL/min Qb=400 mL/min
Urea 196 272 317 352 198 280 330 366
Creatinine 191 255 296 326 194 265 309 341
Phosphate 185 238 272 301 190 250 289 320
Vitamin B12 142 168 179 199 152 183 197 219
KOA (urea) 1232 1483
KUF(mL/hr/mmHg) 63 71
 
  REXEED-21S / R   REXEED-25S / R
Qd=500mL/min Qd=800 mL/min Qd=500mL/min Qd=800 mL/min
Clearance(mL/min) Qb=200 mL/min Qb=300 mL/min Qb=400 mL/min Qb=400 mL/min Qb=200 mL/min Qb=300 mL/min Qb=400 mL/min Qb=400 mL/min
Urea 199 284 340 374 199 287 350 380
Creatinine 195 272 317 352 196 280 330 364
Phosphate 192 257 299 334 194 260 303 346
Vitamin B12 160 194 212 236 163 199 225 251
KOA (urea)(mL/min) 1683 1881
KUF(mL/hr/mmHg) 74 80

•UFR: with bovine plasma, TP=6.5+-0.5g/dL, TMP=6.6kPa (50,,Hg) • Clearance: with saline, TMP = 0kPa (0mmHg) • JOA: Qb=400 mL/min, Qd=800 mL/min
REXEED S Comparison vs US Competitors
Print Comparison (PDF)
  Surface Area (m2) Priming Volume (m2) Clearance Qb300, Qd500 Clearance Qb400, Qd500 Clearance Qb400, Qd800 KoA Urea
Urea Creatinine Phosphate Vit B12 Urea Creatinine Phosphate Vit B12 Urea Creatinine Phosphate Vit B12  
REXEED-15S 1.5 82 272 255 238 168 317 296 272 179 352 326 301 199 1232
Optiflux F160NR 1.5 83 266 238 230 152 308 264 275 157 344 295 296 173 1064
Optiflux F180NR 1.8 99 274 251 238 168 323 286 287 178 358 316 314 203 1239
Polyflux 140H 1.4 94 262 232 220 149 309 266 250 163 - - - - 1040
Polyflux 170H 1.7 115 270 243 232 162 315 282 275 197 - - - - 1190
Exeltra 150 1.5 95 262 242 227 152 305 274 255 163 - - - - 993
Exeltra 170 1.7 105 268 252 232 160 310 286 261 172 - - - - 1103
 
  Surface Area (m2) Priming Volume (m2) Clearance Qb300, Qd500 Clearance Qb400, Qd500 Clearance Qb400, Qd800 KoA Urea
Urea Creatinine Phosphate Vit B12 Urea Creatinine Phosphate Vit B12 Urea Creatinine Phosphate Vit B12  
REXEED-18S 1.8 95 280 265 250 183 330 309 289 197 366 341 320 219 1483
Optiflux F180NR 1.8 99 274 251 238 168 323 286 287 178 358 316 314 203 1239
Optiflux F200NR 2.0 112 277 253 250 173 330 289 290 189 364 325 319 206 1317
Polyflux 170H 1.7 115 270 243 232 162 315 282 275 197 - - - - 1190
Polyflux210H 2.1 125 281 259 249 183 339 303 289 203 - - - - 1500
Exeltra 170 1.7 105 268 252 232 160 310 286 261 172 - - - - 1103
Exeltra 190 1.9 115 273 251 242 168 323 289 276 183 - - - - 1214
 
  Surface Area (m2) Priming Volume (m2) Clearance Qb300, Qd500 Clearance Qb400, Qd500 Clearance Qb400, Qd800 KoA Urea
Urea Creatinine Phosphate Vit B12 Urea Creatinine Phosphate Vit B12 Urea Creatinine Phosphate Vit B12  
REXEED-21S 2.1 112 284 272 257 194 340 317 299 212 374 352 334 236 1683
Optiflux F200NR 2.0 112 277 253 250 173 330 289 290 189 364 325 319 206 1317
Polyflux210H 2.1 125 281 259 249 183 339 303 289 203 - - - - 1500
Exeltra Plus 210 2.1 125 287 277 252 202 350 328 292 222 - - - - 1714
 
  Surface Area (m2) Priming Volume (m2) Clearance Qb300, Qd500 Clearance Qb400, Qd500 Clearance Qb400, Qd800 KoA Urea
Urea Creatinine Phosphate Vit B12 Urea Creatinine Phosphate Vit B12 Urea Creatinine Phosphate Vit B12  
REXEED-25S 2.5 128 287 280 260 199 350 330 303 225 380 364 346 251 1881
Optiflux F200NR 2.0 112 277 253 250 173 330 289 290 189 364 325 319 206 1317
Polyflux210H 2.1 125 281 259 249 183 339 303 289 203 - - - - 1500
Exeltra Plus 210 2.1 125 287 277 252 202 350 328 292 222 - - - - 1714

REXEED R vs US Competitors
Print Comparison (PDF)

  Surface Area (m2) Priming Volume (m2) Clearance Qb300, Qd500 Clearance Qb400, Qd500 Clearance Qb400, Qd800 KoA Urea
Urea Creatinine Phosphate Vit B12 Urea Creatinine Phosphate Vit B12 Urea Creatinine Phosphate Vit B12  
REXEED-15S 1.5 82 272 255 238 168 317 296 272 179 352 326 301 199 1232
Optiflux 180A 1.8 99 274 251 238 168 323 286 287 178 358 316 314 203 1239
Polyflux 17R 1.7 121 254 229 223 159 295 260 253 147 - - - - 880
Polyflux 21R 2.1 152 267 245 240 178 315 282 275 197 - - - - 1100
CT-190G 1.9 115 273 251 242 168 323 289 276 183 - - - - 1218
 
  Surface Area (m2) Priming Volume (m2) Clearance Qb300, Qd500 Clearance Qb400, Qd500 Clearance Qb400, Qd800 KoA Urea
Urea Creatinine Phosphate Vit B12 Urea Creatinine Phosphate Vit B12 Urea Creatinine Phosphate Vit B12  
REXEED-18S 1.8 95 280 265 250 183 330 309 289 197 366 341 320 219 1483
Optiflux 180A 1.8 99 274 251 238 168 323 286 287 178 358 316 314 203 1239
Optiflux 200A 2.0 112 277 253 250 173 330 289 290 189 364 325 319 206 1317
Polyflux 21R 2.1 152 267 245 240 178 315 282 275 197 - - - - 1100
CT-190G 1.9 115 273 251 242 168 323 289 276 183 - - - - 1218
 
  Surface Area (m2) Priming Volume (m2) Clearance Qb300, Qd500 Clearance Qb400, Qd500 Clearance Qb400, Qd800 KoA Urea
Urea Creatinine Phosphate Vit B12 Urea Creatinine Phosphate Vit B12 Urea Creatinine Phosphate Vit B12  
REXEED-21S 2.1 112 284 272 257 194 340 317 299 212 374 352 334 236 1683
Optiflux 200A 2.0 112 277 253 250 173 330 289 290 189 364 325 319 206 1317
Polyflux 21R 2.1 152 267 245 240 178 315 282 275 197 - - - - 1100
Polyflux 24R 2.4 165 274 255 249 192 326 296 288 214 - - - - 1260
 
  Surface Area (m2) Priming Volume (m2) Clearance Qb300, Qd500 Clearance Qb400, Qd500 Clearance Qb400, Qd800 KoA Urea
Urea Creatinine Phosphate Vit B12 Urea Creatinine Phosphate Vit B12 Urea Creatinine Phosphate Vit B12  
REXEED-25S 2.5 128 287 280 260 199 350 330 303 225 380 364 346 251 1881
Optiflux 200A 2.0 112 277 253 250 173 330 289 290 189 364 325 319 206 1317
Polyflux 24R 2.4 165 274 255 249 192 326 296 288 214 - - - - 1260

Balanced and Comprehensive Small Molecule Clearance
REXEED has been developed to provide well balanced and comprehensive small molecule clearance. This is demonstrated by the triangular graph and bar graph below.

Balanced and Comprehensive Small Molecule Clearance Triangle Graph
Balanced and Comprehensive Small Molecule Clearance Bar Graph
Dialysate Flow Test Result
REXEED S Dialysate Flow Test

REXEED S Priming Chart
Download Priming Chart (PDF)
This brochure provides a quick explanation of the priming procedure for the ASAHI WET-TYPE series dialyzer, as an example. This brochure cannot be replaced for the instructions for use (IFU) provided along with dialyzers in the product package. Furthermore, the design of the bloodlines varies among models and among manufacturers. Therefore, other instructions concerning the bloodlines and dialysis machines as well as IFU for ASHAI WET-TYPE series dialyzers, take precedence over this brochure, and these instructions should be referred to carefully before use. The filling fluid of
ASHAI WET-TYPE series dialyzers is not isotonic saline. Inadequate priming may lead to hemolysis or other adverse reactions. During the procedure, one should verify that leakage from the dialyzer, bloodlines, blood ports, and their connecting parts does not occur.

Priming Procedure
REXEED S Priming Chart - Step 1STEP 1:
Place the dialyzer vertically in the holder with the red header (arterial end) facing upward.
REXEED Priming Chart - Step 2STEP 2:
Secure the arterial and venous blood lines to the dialysis machine. Do not attach the blood lines to the dialyzer at this stage.
REXEED S Priming Chart - Step 3STEP 3:
Connect the arterial blood line to the saline bag for Infusion.
REXEED S Priming Chart - Step 4STEP 4:
Open the clamp on the saline line and completely fill the arterial blood line to the dialysis machine with saline.
Thereafter, close the clamp on the arterial blood line.
REXEED S Priming Chart - Step 5STEP 5:
Fill the arterial blood line to the dialyzer with saline by using the blood pump or under gravity. The drip chamber(s) should be filled with saline up to the appropriate level, according to the instructions for the blood line or dialysis machine. Stop the pump or pinch the blood lines with forceps once you have completely filled the arterial blood line to the patient and the one to the dialyzer with saline.
REXEED S Priming Chart - Step 6STEP 6:
Remove the stopper from the red header of the dialyzer and connect the arterial blood line to the red header.
REXEED S Priming Chart - Step 7STEP 7:
Rotate the blue header (venous end) of the dialyzer in the upward direction. Remove the stopper from the blue header of the dialyzer, and connect the venous blood line to the blue header. The other end of the venous blood line should be handled appropriately; for
example, place it in a medical fluid waste bag.
STEP 8:
Open the clamp on the venous blood line and feed saline at approximately 100mLmin by using the blood pump or under gravity until 1L of saline has passed through the dialyzer. If air is trapped in the dialyzer or the blood lines, add more saline for rinsing while gently tapping the dialyzer with the hand or pinching and releasing the blood lines by using forceps until the air is completely removed. Do not attempt to remove the air by tapping the dialyzer with hard instruments, such as forceps, because the instruments may damage the dialyzer. The drip chamber(s) should be filled with saline up to the appropriate level as per the instructions for the blood tubing line or the dialysis machine. Close the clamps on both the arterial and venous blood lines.
REXEED S Priming Chart - Step 8
STEP 9:
Remove the stoppers from the dialysate side of the dialyzer. Connect the dialysate lines of the dialysis machine to the dialysate ports of the dialyzer in a way that the dialysate flows from the blue to the red header, in the direction opposite to the direction of the blood flow. Spilling of the fluid from the dialyzer should be avoided by placing the dialyzer in a horizontal position with the dialysate ports facing upward when connecting the dialysate lines to the dialysate ports. Secure the dialyzer with the red header facing upward. Rinse the dialysate side of the dialyzer with saline at a flow rate of 500 mL/min for 2 or more minutes without negative pressure.
REXEED S Priming Chart - Step 9*The colored dialysate line connectors of the dialysis machine cannot be relied on when deciding the direction in which the fluid flows through the dialyzer. The color of the dialysate line connectors of dialysis machines can differ among manufacturers.
*The priming of the Asahi WET-TYPE series dialyzers is now complete. Treatment may begin, or, according to the unit procedure, saline may be recirculated until treatment begins by connecting the arterial and venous blood lines, opening the saline clamp, and restarting the blood pump at a low flow rate with the red header facing downward. At treatment onset, the dialyzer may be rotated such that the red header faces upward.

REXEED S / R

REXEED S - Single Use, High Flux, Wet, Dialyzers
Product Size M2 Priming
Volume
Membrane Sterilization KOA
(Urea)
Packaging    
REXEED 15S 1.5 82 Polysulfone Gamma-Ray 1232 12 / Case    
REXEED 18S 1.8 95 Polysulfone Gamma-Ray 1483 12 / Case    
REXEED 21S 2.1 112 Polysulfone Gamma-Ray 1683 12 / Case    
REXEED 25S 2.5 128 Polysulfone Gamma-Ray 1881 12 / Case    
 
REXEED R - Multiple Use, High Flux, Wet, Dialyzers
Product Size M2 Priming
Volume
Membrane Sterilization KOA
(Urea)
Packaging    
REXEED 15R 1.5 85 Polysulfone Gamma-Ray 1232 12 / Case    
REXEED 18R 1.8 95 Polysulfone Gamma-Ray 1483 12 / Case    
REXEED 21R 2.1 112 Polysulfone Gamma-Ray 1683 12 / Case    
REXEED 25R 2.5 128 Polysulfone Gamma-Ray 1881 12 / Case